斑马鱼丘脑皮质样回路中的分层感觉处理，这一成果由挪威科技大学Emre Yaksi团队经过不懈努力而取得。该研究于2026年7月2日发表于国际一流学术期刊《科学》杂志上。
在这里，研究小组研究了斑马鱼的苍白质是如何接收和处理感觉信息的，以及它的结构与其他脊椎动物的丘脑皮层回路的比较。该团队发现肾小球前复合体（PG）是一种类似丘脑皮质的通路，是斑马鱼皮层视觉和振动信息的主要来源。PG及其白质投射表现出感觉特异性和地形组织的反应。相比之下，白质神经元表现出地形组织层次，从感觉特异性到多模态和巧合检测非线性响应。他们的研究结果表明，在地形上组织的丘脑皮质样回路中，感觉转换的等级反映了脊椎动物之间的趋同原则。
研究人员表示，丘脑皮层的投射塑造了哺乳动物皮层的功能区域化和平行感觉计算。然而，非哺乳类脊椎动物的丘脑皮质计算原理仍未得到充分研究。
附：英文原文
Title: Hierarchical sensory processing in zebrafish thalamocortical-like circuits
Author: Anh-Tuan Trinh, Anna Maria Ostenrath, Ignacio del Castillo-Berges, Fanchon Cachin, Mina Ko, Susanne Kraus, Bram Serneels, Koichi Kawakami, Emre Yaksi
Issue&Volume: 2026-07-02
Abstract: Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian vertebrates remain underexplored. Here we investigated how the zebrafish pallium, a homolog of the vertebrate cortex, receives and processes sensory information, and how its architecture compares to thalamocortical circuits in other vertebrates. We revealed that the preglomerular complex (PG), a thalamocortical-like pathway, is the primary source of visual and vibrational information to the zebrafish pallium. PG and its pallial projections exhibit sensory-specific and topographically organized responses. In contrast, pallial neurons display topographically organized hierarchies, ranging from sensory-specific to multimodal and coincidence-detecting nonlinear responses. Our results suggest that hierarchies of sensory transformations across topographically organized thalamocortical-like circuits reflect a convergent principle across vertebrates.
DOI: aec2171
Source: https://www.science.org/doi/10.1126/science.aec2171
期刊信息
Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：63.714
官方网址：https://www.sciencemag.org/
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